PAAR-repeat proteins sharpen and diversify the Type VI secretion system spike

  title={PAAR-repeat proteins sharpen and diversify the Type VI secretion system spike},
  author={Mikhail M. Shneider and Sergey A Buth and Brian T. Ho and Marek Basler and John J Mekalanos and Petr G Leiman},
The bacterial type VI secretion system (T6SS) is a large multicomponent, dynamic macromolecular machine that has an important role in the ecology of many Gram-negative bacteria. T6SS is responsible for translocation of a wide range of toxic effector molecules, allowing predatory cells to kill both prokaryotic as well as eukaryotic prey cells. The T6SS organelle is functionally analogous to contractile tails of bacteriophages and is thought to attack cells by initially penetrating them with a… CONTINUE READING
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