P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation

  title={P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation},
  author={Ping Li and Hidemasa Goto and Kousuke Kasahara and M. Matsuyama and Zhonghua Wang and Yasushi Yatabe and Tohru Kiyono and Masaki Inagaki},
  booktitle={Molecular biology of the cell},
The ataxia telangiectasia mutated- and rad3-related kinase (ATR)/Chk1 pathway is a sentinel of cell cycle progression. On the other hand, the Ras/mitogen-activated protein kinase/90-kDa ribosomal S6 kinase (p90 RSK) pathway is a central node in cell signaling downstream of growth factors. These pathways are closely correlated in cell proliferation, but their interaction is largely unknown. Here we show that Chk1 is phosphorylated predominantly at Ser-280 and translocated from cytoplasm to… CONTINUE READING


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