P75 and phosphorylated c-Jun are differentially regulated in spinal motoneurons following axotomy in rats☆

Abstract

The neurotrophin receptor (p75) activates the c-Jun N-terminal kinase (JNK) pathway. Activation of JNK and its substrate c-Jun can cause apoptosis. Here we evaluate the role of p75 in spinal motoneurons by comparing immunoreactivity for p75 and phosphorylated c-Jun (p-c-Jun), the production of JNK activation in axotomized motoneurons in postnatal day (PN)1… (More)
DOI: 10.3969/j.issn.1673-5374.2012.26.001

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