P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA.

  title={P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA.},
  author={Yoichiro Yoshida and Hiroto Izumi and Takayuki Torigoe and Hiroshi Ishiguchi and Hideaki Itoh and Dongchon Kang and Kimitoshi Kohno},
  journal={Cancer research},
  volume={63 13},
Mitochondrial transcription factor A (mtTFA; also designated Tfam) is necessary for both transcription and maintenance of mitochondrial DNA. mtTFA preferentially recognizes cisplatin-damaged DNA, as well as oxidized DNA. Increased apoptosis has been observed in mtTFA knockout animals, suggesting that mtTFA is involved in apoptosis. A fraction of p53 protein localizes to mitochondria at the onset of p53-dependent apoptosis, but not during p53-independent apoptosis. Using immunochemical… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 67 extracted citations

Mechanisms of Mitochondrial DNA Repair in Mammals

Biochemistry (Moscow) • 2018
View 6 Excerpts
Highly Influenced

Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2011
View 3 Excerpts
Highly Influenced

Emerging Roles of p53 Family Members in Glucose Metabolism

International journal of molecular sciences • 2018
View 1 Excerpt

Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome

Oxidative medicine and cellular longevity • 2017
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 39 references

A potential role of p53 and WOX1 in mitochondrial apoptosis (review).

International journal of molecular medicine • 2002

Human mitochondrial transcription factor A binds preferentially to oxidatively damaged DNA.

Biochemical and biophysical research communications • 2002
View 10 Excerpts

Direct influence of the p53 tumor suppressor on mitochondrial biogenesis and function.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2001

Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression.

Proceedings of the National Academy of Sciences of the United States of America • 2001
View 2 Excerpts

Similar Papers

Loading similar papers…