P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA.

@article{Yoshida2003P53PI,
  title={P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA.},
  author={Yoichiro Yoshida and Hiroto Izumi and Takayuki Torigoe and Hiroshi Ishiguchi and Hideaki Itoh and Dongchon Kang and Kimitoshi Kohno},
  journal={Cancer research},
  year={2003},
  volume={63 13},
  pages={3729-34}
}
Mitochondrial transcription factor A (mtTFA; also designated Tfam) is necessary for both transcription and maintenance of mitochondrial DNA. mtTFA preferentially recognizes cisplatin-damaged DNA, as well as oxidized DNA. Increased apoptosis has been observed in mtTFA knockout animals, suggesting that mtTFA is involved in apoptosis. A fraction of p53 protein localizes to mitochondria at the onset of p53-dependent apoptosis, but not during p53-independent apoptosis. Using immunochemical… CONTINUE READING

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