P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.

@article{Bradford2003P53MC,
  title={P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.},
  author={Carol R Bradford and Shaobo Zhu and Haruko Ogawa and Tetsuya Ogawa and Matthew L Ubell and Ajita Narayan and Garfield Johnson and Gregory T. Wolf and Susan G Fisher and Thomas E. Carey},
  journal={Head & neck},
  year={2003},
  volume={25 8},
  pages={
          654-61
        }
}
  • Carol R Bradford, Shaobo Zhu, +7 authors Thomas E. Carey
  • Published in Head & neck 2003
  • Medicine
  • BACKGROUND A critical factor for successful organ preservation treatment in head and neck cancer may be selecting tumors that respond to chemotherapy and radiation. Previous results in patients indicated that tumors that overexpressed p53 were more sensitive to chemotherapy than those that did not overexpress p53. METHODS To determine the relationship of p53 mutations to sensitivity to cisplatin in vitro, 23 head and neck squamous cell carcinoma (HNSCC) cell lines were analyzed for cisplatin… CONTINUE READING

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    Overexpression of p53 predicts organ preservation using induction chemotherapy and radiation in patients with advanced laryngeal cancer. Department of Veterans Affairs Laryngeal Cancer Study Group.

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