P53 mediates ceramide-induced apoptosis in SKN-SH cells

@article{Kim2002P53MC,
  title={P53 mediates ceramide-induced apoptosis in SKN-SH cells},
  author={Sung Young Kim and H P Chae and Jae-Hyung Bach and Myoung Woo Lee and Kyung Yong Kim and Won Bok Lee and Young-Min Jung and Joseph V. Bonventre and Yoo-hun Suh},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={2020-2028}
}
Ceramide induces apoptotic cell death in a dose- and time-dependent manner in neuroblastoma SKN-SH cells. Pretreatment with caspase inhibitors blocks cell death, suggesting that a set of caspase activities including caspase 1, as well as caspase 3, are involved in ceramide-induced apoptosis in SKN-SH cells. Treatment with a caspase inhibitor 3 h after ceramide addition did not inhibit cell death, although caspase activity was substantially reduced. Ceramide-induced apoptosis is accompanied by… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-9 of 9 references

Biochem

W El-Assaad, M El-Sabban, C Awaraji, N Abboushi, GS. Dbaibo
J., 336, 735 ± 741. • 1998

Toxicol

C Choisy-Rossi, P Reisdorf, E. Yonish-Rouach
Lett., 102 ± 103, 491 ± 496. • 1998
View 2 Excerpts

Br

Thornberry NA.
Med. Bull., 53, 478 ± 490. • 1997

J

H Zha, C Aime-Sempe, T Sato, JC. Reed
Biol. Chem., 271, 7440 ± 7444. • 1996

Proc

J Zhang, N Alter, +3 authors YA. Hannun
Natl. Acad. Sci. USA, 93, 5325 ± 5328. • 1996

Science, 270, 96 ± 99

Korsmeyer SJ.
Laemmli UK. (1970). Nature, 227, 680 ± 685. Levine AJ. (1997). Cell, 88, 323 ± 331. Lightle SA, Oakley JI and Nikolova-Karakashian MN. • 1995

Mol

TG Graeber, JF Peterson, +3 authors AJ. Giaccia
Cell Biol., 14, 6264 ± 6277. • 1994
View 1 Excerpt

Oncogene , 9 , 1791 ± 1798

M Selvakumaran, HK Lin, +3 authors JC Reed
1994
View 1 Excerpt

Anal

Bradford MM.
Biochem., 72, 248 ± 254. • 1976

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