P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis.

@article{Han2002P53mediatedIO,
  title={P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis.},
  author={Jeong Ae Han and Jong-Il Kim and Pat P. Ongusaha and Daniel H. Hwang and Leslie R. Ballou and Anurag Mahale and Stuart A. Aaronson and Sam W. Lee},
  journal={The EMBO journal},
  year={2002},
  volume={21 21},
  pages={
          5635-44
        }
}
The identification of transcriptional targets of the tumor suppressor p53 is crucial in understanding mechanisms by which it affects cellular outcomes. Through expression array analysis, we identified cyclooxygenase 2 (Cox-2), whose expression was inducible by wild-type p53 and DNA damage. We also found that p53-induced Cox-2 expression results from p53-mediated activation of the Ras/Raf/MAPK cascade, as demonstrated by suppression of Cox-2 induction in response to p53 by dominant-negative Ras… CONTINUE READING
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