P53-mediated G(1)/S checkpoint dysfunction in lymphocytes from Alzheimer's disease patients.

To date, Alzheimer disease (AD) is still difficult to be diagnosed in its earliest stage. The cell cycle aberrations may be the earliest neuropathological events detected in AD thus far. The cell cycle regulatory failure in AD occurring at "G(1)/S transition checkpoint" which is mediated by the tumor suppressor protein p53 has been identified. Herein, we… CONTINUE READING