P53 levels determine outcome during β-catenin tumor initiation and metastasis in the mammary gland and male germ cells

Abstract

β-catenin, an oncogene, and P53, a tumor suppressor, are common targets of mutation in human cancers. It has been observed that P53 is often inactivated in tumors involving β-catenin activation. In an attempt to model this situation in vivo, we crossed the previously characterized MMTV-ΔN-β-catenin mouse with the P53 knockout mouse. Female multiparous mice… (More)
DOI: 10.1038/sj.onc.1209391

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@article{Ridgeway2006P53LD, title={P53 levels determine outcome during β-catenin tumor initiation and metastasis in the mammary gland and male germ cells}, author={Alan G Ridgeway and Jennifer McMenamin and Philip Leder}, journal={Oncogene}, year={2006}, volume={25}, pages={3518-3527} }