P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis.

  title={P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis.},
  author={Munekazu Yamakuchi and Craig D Lotterman and Clare Bao and Ralph H. Hruban and Baktiar O. Karim and Joshua T. Mendell and David Leonard Huso and Charles J Lowenstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 14},
The pathway involving the tumor suppressor gene TP53 can regulate tumor angiogenesis by unclear mechanisms. Here we show that p53 regulates hypoxic signaling through the transcriptional regulation of microRNA-107 (miR-107). We found that miR-107 is a microRNA expressed by human colon cancer specimens and regulated by p53. miR-107 decreases hypoxia signaling by suppressing expression of hypoxia inducible factor-1beta (HIF-1beta). Knockdown of endogenous miR-107 enhances HIF-1beta expression and… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 163 extracted citations

Similar Papers

Loading similar papers…