P53 gene polymorphisms and breast cancer risk in Arab women

@article{Alawadi2011P53GP,
  title={P53 gene polymorphisms and breast cancer risk in Arab women},
  author={Shafika Alawadi and Lina Ghabreau and Mervat Alsaleh and Zainab Hashim Abdulaziz and Mohamed Rafeek and Nizar Akil and Moussa Alkhalaf},
  journal={Medical Oncology},
  year={2011},
  volume={28},
  pages={709-715}
}
The association between polymorphisms in the p53 tumor suppressor gene and breast cancer risk has been studied in many human populations with conflicting conclusions. However, similar studies in Arab women are not available, and the status of these polymorphisms in this ethnic population is not known. We investigated the status of four known p53 gene polymorphisms and their possible role in breast cancer risk in Arab women. Genotyping was performed for 288 breast cancer women and 188 controls… 
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TP53 codon 72 polymorphism and breast cancer risk in Bangladeshi population
TLDR
The data suggest that mutant (Pro/Pro) homozygosity at codon 72 of TP53 gene is significantly associated with breast cancer susceptibility in Bangladeshi women, and this association was significantly related to lactating status.
The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women.
TLDR
The results indicate that the TP53 gene could play a major role in breast carcinogenesis and the early onset of the disease among Saudi women and the codon 47 polymorphism appears to have no role in this disease.
p53 codon 72 polymorphism and breast cancer risk: A meta-analysis
TLDR
A meta-analysis suggests that the p53 codon 72 Pro/Pro + Arg/Pro genotypes are not associated with an increased risk of breast cancer.
TP53 polymorphisms in sporadic North Indian breast cancer patients.
TLDR
It is indicated that among the five TP53 polymorphisms investigated, the p.R72P polymorphism, and the RP-A1A1 and RP-GG genotype combination contribute to breast cancer susceptibility in North Indians.
The TP53 intron 6 G13964C polymorphism and risk of thyroid and breast cancer development in the Iranian Azeri population.
TLDR
There was no significant association between the TP53 intron 6 G13964C polymorphism and risk of development of both thyroid and breast cancer in Iranian-Azeri patients.
p53 exon 4 (codon 72) polymorphism and exon 7 (codon 249) mutation in breast cancer patients in southern region (Madurai) of Tamil Nadu.
TLDR
There is no risk for exon 4 with Arg/Arg or Pro/Pro polymorphisms in the p53 gene and there is no strong correlation between breast cancer patients and mutation in exon 7 codon 249 in South Indian women.
Lack of influence of TP53 Arg72Pro and 16bp duplication polymorphisms on risk of breast cancer in Iran.
TLDR
Whether p53 codon 72 and PIN3 Ins16 bp may be associated with an increased risk for breast cancer in female patients from the northwest of Iran is examined to establish no statistical significant distinctions between the genotypes and allele frequency were found.
Breast cancer risk in relation to TP53 codon 72 and CDH1 gene polymorphisms in the Bangladeshi women
TLDR
It is demonstrated that P53Arg72Pro and CDH1rs16260 polymorphisms are associated with elevated breast cancer risk in the Bangladeshi population.
Association of Trp53 arg72pro polymorphic variants with breast cancer - a case control study in south Indian population
TLDR
Although there was no statistically significant difference in the allelic and genotypic distribution, higher number of arg allele was observed in breast cancer patients when compared to the controls suggesting that the arg allele may be associated with predisposing women to breast cancer.
Lack of association of intron 3 16 bp polymorphism of TP53 with breast cancer among Iranian-Azeri patients.
TLDR
The intron 3 16 bp duplication polymorphism of p53 could not be assessed as a marker of risk factor for predisposition to breast cancer in Azeri population, however, a high frequency of A2 allele (22.1%) in the population suggested that intron 2 15 bp duplicated polymorphism may be a valuable marker for study in other cancers with well designed large groups.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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