P53 gene polymorphisms and breast cancer risk in Arab women

@article{Alawadi2011P53GP,
  title={P53 gene polymorphisms and breast cancer risk in Arab women},
  author={Shafika Alawadi and Lina Ghabreau and Mervat Alsaleh and Zainab Hashim Abdulaziz and Mohamed Rafeek and Nizar Akil and Moussa Alkhalaf},
  journal={Medical Oncology},
  year={2011},
  volume={28},
  pages={709-715}
}
The association between polymorphisms in the p53 tumor suppressor gene and breast cancer risk has been studied in many human populations with conflicting conclusions. However, similar studies in Arab women are not available, and the status of these polymorphisms in this ethnic population is not known. We investigated the status of four known p53 gene polymorphisms and their possible role in breast cancer risk in Arab women. Genotyping was performed for 288 breast cancer women and 188 controls… 
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TLDR
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TLDR
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TLDR
Whether p53 codon 72 and PIN3 Ins16 bp may be associated with an increased risk for breast cancer in female patients from the northwest of Iran is examined to establish no statistical significant distinctions between the genotypes and allele frequency were found.
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TLDR
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Association of Trp53 arg72pro polymorphic variants with breast cancer - a case control study in south Indian population
TLDR
Although there was no statistically significant difference in the allelic and genotypic distribution, higher number of arg allele was observed in breast cancer patients when compared to the controls suggesting that the arg allele may be associated with predisposing women to breast cancer.
Lack of association of intron 3 16 bp polymorphism of TP53 with breast cancer among Iranian-Azeri patients.
TLDR
The intron 3 16 bp duplication polymorphism of p53 could not be assessed as a marker of risk factor for predisposition to breast cancer in Azeri population, however, a high frequency of A2 allele (22.1%) in the population suggested that intron 2 15 bp duplicated polymorphism may be a valuable marker for study in other cancers with well designed large groups.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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