P53 gene mutations in osteosarcomas in the dog.

Abstract

Osteosarcomas in 18 dogs were examined for the presence of p53 mutations in exons 4-8 by single strand conformation polymorphism (SSCP) analysis, followed by sequence analysis in tumors demonstrating abnormal bands in the SSCP analysis. P53 mutations were found in four of the primary tumors in 17 dogs. Metastases studied in two of these dogs in which the primary tumor contained only wild type p53 did not contain mutations, nor those of one dog in which the primary tumor was not studied. The alterations that were found included three missense mutations and one 3 bp insertion.

Statistics

0102030'00'02'04'06'08'10'12'14'16
Citations per Year

59 Citations

Semantic Scholar estimates that this publication has 59 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Leeuwen1997P53GM, title={P53 gene mutations in osteosarcomas in the dog.}, author={Inge van Leeuwen and C. J. Cornelisse and Wim Misdorp and S A Goedegebuure and Jolle Kirpensteijn and Gerard R{\"{o}els Rutteman}, journal={Cancer letters}, year={1997}, volume={111 1-2}, pages={173-8} }