P53 expression in breast cancer.

  title={P53 expression in breast cancer.},
  author={Giorgio Cattoretti and Franco Rilke and Salvatore Ambrogio Andreola and Lucia D'Amato and Domenico Delia},
  journal={International journal of cancer},
  volume={41 2},
Immunohistochemical evaluation of 200 primary breast cancers with the anti-p53 mouse monoclonal antibody (MAb) PAb421 showed positivity in nuclei of malignant cells in 31 cases (15.5%). PAb421+ cases were significantly more frequently epidermal growth factor receptor (EGF-R)-positive (67.7%; p less than 0.001) and estrogen receptor (ER)-negative (73.3%; p less than 0.001); they displayed surface histocompatibility class-1 (80.6%; p less than 0.01) and 11 (74.2%; p less than 0.05) antigens. Low… CONTINUE READING