P53-dependent suppression of the human calcyclin gene (S100A6): the role of Sp1 and of NFkappaB.

@article{Krliczak2008P53dependentSO,
  title={P53-dependent suppression of the human calcyclin gene (S100A6): the role of Sp1 and of NFkappaB.},
  author={Weronika Kr{\'o}liczak and Maciej Pietrzak and Monika Puzianowska-Kuźnicka},
  journal={Acta biochimica Polonica},
  year={2008},
  volume={55 3},
  pages={
          559-70
        }
}
Calcyclin (S100A6) is believed to participate in cell cycle control. It was, however, unclear if its expression depends on p53, a key regulator of apoptosis and cell cycle. We therefore performed transcription regulation assays in HeLa cells and found that wild type p53 suppressed the S100A6 promoter up to 12-fold in a dose-dependent manner. In contrast, the well-characterized V143A, R175H, R249S, and L344A p53 mutants cloned from human cancers suppressed this promoter with a 6 to 9-fold lower… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 57 REFERENCES

Inhibition of cyclooxygenase-2 gene expression by p53.

  • The Journal of biological chemistry
  • 1999
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

S100A6 protein as a marker for differential diagnosis of cholangiocarcinoma from hepatocellular carcinoma.

  • Hepatology research : the official journal of the Japan Society of Hepatology
  • 2002
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

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