P53 codon 72 polymorphism and BRCA 1 and 2 mutations in ovarian epithelial malignancies in black South Africans.

@article{Pegoraro2003P53C7,
  title={P53 codon 72 polymorphism and BRCA 1 and 2 mutations in ovarian epithelial malignancies in black South Africans.},
  author={Rosemary J. Pegoraro and Manivasan Moodley and Lee Rom and Runjan Chetty and Jack Moodley},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2003},
  volume={13 4},
  pages={444-9}
}
Mutations in the BRCA and p53 tumor suppressor genes are implicated in the oncogenesis of ovarian tumors although their exact roles remain unclear. Despite recognized ethnic differences in the frequency of ovarian cancer and in genetic polymorphisms between populations, studies carried out so far have focused almost entirely on Caucasian subjects. In this study, undertaken at King Edward VIII Hospital, Durban, South Africa, we examined blood and/or primary epithelial ovarian tumor tissue from… CONTINUE READING
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