P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors

Abstract

Naturally occurring sympathetic neuron death is the result of two apoptotic signaling events: one normally suppressed by NGF/TrkA survival signals, and a second activated by the p75 neurotrophin receptor. Here we demonstrate that the p53 tumor suppressor protein, likely as induced by the MEKK-JNK pathway, is an essential component of both of these apoptotic… (More)

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@article{Aloyz1998P53IE, title={P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors }, author={Raquel S. Aloyz and Shernaz X. Bamji and Christine D Pozniak and Jean G. Toma and Jasvinder K Atwal and David R Kaplan and Freda D. Miller}, journal={The Journal of Cell Biology}, year={1998}, volume={143}, pages={1691 - 1703} }