P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.

@article{Huang2000P47phoxdeficientNO,
  title={P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.},
  author={Christopher K Huang and Lijun Zhan and Michael O Hannigan and Youxi Ai and Thomas L. Leto},
  journal={Journal of leukocyte biology},
  year={2000},
  volume={67 2},
  pages={210-5}
}
Deficiencies in neutrophil NADPH oxidase proteins have been demonstrated in humans with chronic granulomatous disease. However, no spontaneous mutation in murine NADPH oxidase has been reported. In this study we report that neutrophils from the diabetic mouse strains, C57BL/6J-m heterozygous lean (lepr(db/+)) and homozygous obese (lepr(db/db)) mice produced no superoxide on stimulation. An absence of intact p47(phox) but not other oxidase proteins was observed in both mouse strains through the… CONTINUE READING

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