P450s in Microbial Sterol Biosynthesis and Drug Targets


The diversity of cytochromes P450s (CYP) in species from various Kingdoms of Life is extensive, sometimes comprising more than 1% of coding genes. Some bacteria do not contain CYP genes while in others, such as the actinomycetes, they are numerous. Microbial eukaryotes usually contain at least CYP51, the ancestral activity needed for sterol 14-demethylation… (More)


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