P450 structures and oxidative metabolism of xenobiotics.

@article{Lewis2003P450SA,
  title={P450 structures and oxidative metabolism of xenobiotics.},
  author={David F. V. Lewis},
  journal={Pharmacogenomics},
  year={2003},
  volume={4 4},
  pages={387-95}
}
This review focuses on the structural models for cytochrome P450, which are improving our knowledge and understanding of the P450 catalytic cycle, and the way in which substrates bind to the enzyme leading to catalytic conversion and subsequent formation of mono-oxygenated metabolites. Various stages in the P450 reaction cycle have now been investigated using X-ray crystallography and electronic structure calculations, whereas homology modeling of mammalian P450s is currently revealing… CONTINUE READING