P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity.

@article{Hart2008P450OG,
  title={P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity.},
  author={Steven N. Hart and Xiao-bo Zhong},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2008},
  volume={4 4},
  pages={439-52}
}
BACKGROUND Cytochrome P450 oxidoreductase (POR) is the only electron donor for all microsomal cytochrome P450 monooxygenases (CYP), some of which are phase I drug-metabolizing enzymes, responsible for oxidation of more than 80% of drugs. OBJECTIVES To provide a more thorough understanding of the genetic factors influencing drug metabolism, we address the role of genetic polymorphisms in the POR gene, and their implications for drug metabolism and cytotoxicity. METHODS The scope of this… CONTINUE READING

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