P450 enzymes and Parkinson's disease: the story so far.

@article{Riedl1998P450EA,
  title={P450 enzymes and Parkinson's disease: the story so far.},
  author={Andrew G Riedl and Peter M Watts and Peter Jenner and Christopher Marsden},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={1998},
  volume={13 2},
  pages={
          212-20
        }
}
Environmental or endogenous toxins may cause nigral cell death in Parkinson's disease (PD) as a result of genetic susceptibility conferred by altered expression of P450 enzymes. Attention over the last 10 years has focused on CYP2D6 polymorphisms and susceptibility to PD. This review summarizes reports arising from both phenotypic and genotypic studies involving CYP2D6 and PD. Phenotypic studies have failed to support a link between CYP2D6 and PD. The more powerful genetic studies initially… CONTINUE READING

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