P38alpha-selective mitogen-activated protein kinase inhibitor for improvement of cultured human islet recovery.

OBJECTIVES We investigated whether the recovery of cultured human islets is improved through the addition of a p38alpha-selective mitogen-activated protein kinase inhibitor, SD-282, to clinically used serum-free culture medium. METHODS Immediately after isolation, islets were cultured for 24 hours in medium alone (control) or medium containing dimethyl… CONTINUE READING