P38-associated pathway involvement in apoptosis induced by photodynamic therapy with Lonicera japonica in human lung squamous carcinoma CH27 cells.

@article{Leung2008P38associatedPI,
  title={P38-associated pathway involvement in apoptosis induced by photodynamic therapy with Lonicera japonica in human lung squamous carcinoma CH27 cells.},
  author={Henry W-C Leung and M-J Hour and W. Chang and Y-C Wu and M J Lai and M Wang and H Z Lee},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2008},
  volume={46 11},
  pages={3389-400}
}
Photodynamic therapy (PDT) is an effective therapy for local malignant tumors. Lonicera japonica was found to have the anti-tumor effect. The aim of this study is to explore the mechanisms of apoptosis induced by PDT in lung CH27 carcinoma cells with alcohol extract from Lonicera japonica as photosensitizer. Our study indicated that Lonicera japonica extracts exhibited significant photocytotoxicity in CH27 cells at a concentration range of 50-150 microg/ml, with 0.4-1.2J/cm2 light dose. PDT… CONTINUE READING
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