• Chemistry
  • Published 2010

P38 Signal Cascades in Hyperosmolarity-Induced Mucous Hypersecretion

  title={P38 Signal Cascades in Hyperosmolarity-Induced Mucous Hypersecretion},
  author={Li Wen-feng and Zhou Xiang-dong},
Objective To explore the mechanism of signal cascades in hyperosmolarity-induced mucous hypersecretion.Methods NCl-H292 airway epithelial cells were cultured in 545,695,855,1 055 and 1 280 mOsm/L hypertonic saline solution.At the same time,1 280 mOsm/L hypertonic saline was uesd as a stimulus to P38 inhibitor SB203580,c-jun N-terminal kinase(JNK) inhibitor SP600125 and extracellular signal-regulated protein kinase(ERK)-specific inhibitor U0126 were uesd as the intervention factors.The… CONTINUE READING