P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth.

@article{Zhou2014P300BT,
  title={P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth.},
  author={Jun Zhou and Songhua Zhan and Wenli Tan and Ruixin Cheng and Hangjun Gong and Qiong Zhu},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={444 3},
  pages={387-90}
}
MTA2 is a member of metastasis associated family, which is highly expressed in several solid tumors and associated with tumor cells migration and invasion. Here, we report that MTA2 is acetylated at K152 and histone acetyltransferase p300 binds to and acetylates MTA2. Furthermore, mutation of the MTA2 acetylation site inhibits the growth of colorectal cancer cells and migration and invasion of Rat1 fibroblasts. These results reveal a novel post-translational regulation of MTA2 by the way of… CONTINUE READING

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