P2u receptor-mediated release of endothelium-derived relaxing factor/nitric oxide and endothelium-derived hyperpolarizing factor from cerebrovascular endothelium in rats.

@article{You1999P2uRR,
  title={P2u receptor-mediated release of endothelium-derived relaxing factor/nitric oxide and endothelium-derived hyperpolarizing factor from cerebrovascular endothelium in rats.},
  author={Junping You and Troy D. Johnson and Sean P. Marrelli and Jean Vivien Mombouli and Robert M. Jr. Bryan},
  journal={Stroke},
  year={1999},
  volume={30 5},
  pages={1125-33}
}
BACKGROUND AND PURPOSE Stimulation of P2u purinoceptors by UTP on endothelium dilates the rat middle cerebral artery (MCA) through the release of endothelium-derived relaxing factor/nitric oxide (EDRF/NO) and an unknown relaxing factor. The purpose of this study was to determine whether this unknown relaxing factor is endothelium-derived hyperpolarizing factor (EDHF). METHODS Rat MCAs were isolated, cannulated, pressurized, and luminally perfused. UTP was added to the luminal perfusate to… CONTINUE READING