P2Y2 receptor regulates VCAM-1 membrane and soluble forms and eosinophil accumulation during lung inflammation.

@article{Vanderstocken2010P2Y2RR,
  title={P2Y2 receptor regulates VCAM-1 membrane and soluble forms and eosinophil accumulation during lung inflammation.},
  author={Gilles Vanderstocken and Benjamin Bondue and Michael Horckmans and Larissa di Pietrantonio and Bernard Robaye and J. M. Boeynaems and Didier Communi},
  journal={Journal of immunology},
  year={2010},
  volume={185 6},
  pages={3702-7}
}
ATP has been defined as a key mediator of asthma. In this study, we evaluated lung inflammation in mice deficient for the P2Y(2) purinergic receptor. We observed that eosinophil accumulation, a distinctive feature of lung allergic inflammation, was defective in OVA-treated P2Y(2)-deficient mice compared with OVA-treated wild type animals. Interestingly, the… CONTINUE READING