P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries.

@article{Andr2003P2Y12RP,
  title={P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries.},
  author={Patrick Andr{\'e} and Suzanne M Delaney and Thomas J Larocca and Diana E Vincent and Francis R Deguzman and Marzena Jurek and Beverley Koller and David R. Phillips and Pamela B Conley},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={112 3},
  pages={398-406}
}
The critical role for ADP in arterial thrombogenesis was established by the clinical success of P2Y12 antagonists, currently used at doses that block 40-50% of the P2Y12 on platelets. This study was designed to determine the role of P2Y12 in platelet thrombosis and how its complete absence affects the thrombotic process. P2Y12-null mice were generated by a gene-targeting strategy. Using an in vivo mesenteric artery injury model and real-time continuous analysis of the thrombotic process, we… CONTINUE READING