P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury.

@article{TozakiSaitoh2008P2Y12RI,
  title={P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury.},
  author={Hidetoshi Tozaki-Saitoh and Makoto Tsuda and Hiroyuki Miyata and Kazuaki Ueda and Shinichi Kohsaka and Kazuhide Inoue},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 19},
  pages={
          4949-56
        }
}
Extracellular nucleotides have been implicated as signaling molecules used by microglia to sense adverse physiological conditions, such as neuronal damage. They act through purinoceptors, especially the G-protein-coupled P2Y receptor P2Y(12)R. Emerging evidence has indicated that activated spinal microglia responding to nerve injury are key cellular intermediaries in the resulting highly debilitating chronic pain state, namely neuropathic pain. However, the role of microglial P2Y(12)Rs in… CONTINUE READING
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