P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation.

@article{Shankar2006P2Y12RP,
  title={P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation.},
  author={Haripriya Shankar and Angel Garc{\'i}a and Janani Prabhakar and Sung-Hoon Kim and Satya P Kunapuli},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2006},
  volume={4 3},
  pages={
          638-47
        }
}
BACKGROUND Thromboxane A2 (TXA2) is a positive feedback lipid mediator that is generated upon stimulation of platelets with various agonists. Aspirin works as an antithrombotic drug by blocking the generation of TXA2. The aim of this study was to evaluate the role of the purinergic P2Y receptors in thrombin-induced TXA2 generation. RESULTS PAR1-activating peptide (SFLLRN), PAR4-activating peptide (AYPGKF), and thrombin, induced the activation of cytosolic phospholipase A2 (cPLA2), release of… CONTINUE READING

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