P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose.

@article{Beckerath2005P2Y12GH,
  title={P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose.},
  author={Nicolas von Beckerath and Olga von Beckerath and Werner Koch and Marianne Eichinger and Albert Schoemig and Adnan Kastrati},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={2005},
  volume={16 3},
  pages={199-204}
}
A large variability in the antiplatelet response to clopidogrel has been consistently reported. Recently, a P2Y12 haplotype was shown to be associated with enhanced adenosine diphosphate (ADP)-induced platelet aggregation in healthy volunteers. The aim of this study was to test in patients (n = 416) scheduled for coronary artery stenting whether P2Y12 haplotype H2 carriage is associated with increased ADP-induced platelet aggregation after administration of a 600 mg loading dose of clopidogrel… CONTINUE READING

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