P2Y12 and P2Y13 receptors involved in ADPβs induced the release of IL-1β, IL-6 and TNF-α from cultured dorsal horn microglia

@inproceedings{Liu2017P2Y12AP,
  title={P2Y12 and P2Y13 receptors involved in ADPβs induced the release of IL-1β, IL-6 and TNF-α from cultured dorsal horn microglia},
  author={Pei-Wen Liu and Ming-Xia Yue and Rui Zhou and Juan Niu and Du-Juan Huang and Tao Xu and Pei Luo and Xiao-hong Liu and Jun-Wei Zeng},
  booktitle={Journal of pain research},
  year={2017}
}
OBJECTIVE P2 receptors have been implicated in the release of neurotransmitter and pro-inflammatory cytokines due to their response to neuroexcitatory substances in the microglia. Dorsal horn P2Y12 and P2Y13 receptors are involved in the development of pain behavior induced by peripheral nerve injury. However, it is not known whether P2Y12 and P2Y13 receptors activation is associated with the expression and the release of interleukin-1B (IL-1β), interleukin-6 (IL-6), tumor necrosis factor… CONTINUE READING
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