P2Y1 receptor modulation of the pre-Bötzinger complex inspiratory rhythm generating network in vitro.

  title={P2Y1 receptor modulation of the pre-B{\"o}tzinger complex inspiratory rhythm generating network in vitro.},
  author={Amanda R. Lorier and Adrianne G. Huxtable and Dean M. Robinson and Janusz Lipski and Gary D. Housley and Gregory D Funk},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={27 5},
ATP is released during hypoxia from the ventrolateral medulla (VLM) and activates purinergic P2 receptors (P2Rs) at unknown loci to offset the secondary hypoxic depression of breathing. In this study, we used rhythmically active medullary slices from neonatal rat to map, in relation to anatomical and molecular markers of the pre-Bötzinger complex (preBötC) (a proposed site of rhythm generation), the effects of ATP on respiratory rhythm and identify the P2R subtypes responsible for these actions… CONTINUE READING


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