P2Y1 purinoreceptors are fundamental to inhibitory motor control of murine colonic excitability and transit.

@article{Hwang2012P2Y1PA,
  title={P2Y1 purinoreceptors are fundamental to inhibitory motor control of murine colonic excitability and transit.},
  author={Sung Jin Hwang and Peter J A Blair and Leonie Durnin and Violeta N Mutafova-Yambolieva and Kenton M. Sanders and Sean M Ward},
  journal={The Journal of physiology},
  year={2012},
  volume={590 8},
  pages={
          1957-72
        }
}
Activation of enteric inhibitory motor neurons causes inhibitory junctional potentials (IJPs) and muscle relaxation in mammalian gastrointestinal (GI) muscles, including humans. IJPs in many GI muscles are bi-phasic with a fast initial hyperpolarization (fIJP) due to release of a purine neurotransmitter and a slower hyperpolarization component (sIJP) due to release of nitric oxide. We sought to characterize the nature of the post-junctional receptor(s) involved in transducing purinergic neural… CONTINUE READING
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