P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells.

@article{Lyubchenko2011P2Y1AP,
  title={P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells.},
  author={Taras A Lyubchenko and Heather N. Woodward and Kristopher D. Veo and Nana Burns and Hala Nijmeh and Ganna A Liubchenko and Kurt R Stenmark and Evgenia V. Gerasimovskaya},
  journal={American journal of physiology. Cell physiology},
  year={2011},
  volume={300 2},
  pages={C266-75}
}
Extracellular ATP and ADP have been shown to exhibit potent angiogenic effects on pulmonary artery adventitial vasa vasorum endothelial cells (VVEC). However, the molecular signaling mechanisms of extracellular nucleotide-mediated angiogenesis remain not fully elucidated. Since elevation of intracellular Ca(2+) concentration ([Ca(2+)](i)) is required for cell proliferation and occurs in response to extracellular nucleotides, this study was undertaken to delineate the purinergic receptor… CONTINUE READING
20 Citations
57 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Similar Papers

Loading similar papers…