P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms.

@article{Hardy2005P2Y1AP,
  title={P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms.},
  author={Adam Hardy and Pamela B Conley and Jiansong Luo and Jeffrey L. Benovic and Alastair W Poole and Stuart James Mundell},
  journal={Blood},
  year={2005},
  volume={105 9},
  pages={3552-60}
}
Adenosine 5'-diphosphate (ADP) plays a central role in regulating platelet function by the activation of the G protein-coupled receptors P2Y(1) and P2Y(12). Although it is well established that aggregation responses of platelets to ADP desensitize, the underlying mechanisms involved remain unclear. In this study we demonstrate that P2Y(1)- and P2Y(12)-mediated platelet responses desensitize rapidly. Furthermore, we have established that these receptors desensitize by different kinase-dependent… CONTINUE READING