P2Y receptors contribute to ATP-induced increases in intracellular calcium in differentiated but not undifferentiated PC12 cells.

@article{Arslan2000P2YRC,
  title={P2Y receptors contribute to ATP-induced increases in intracellular calcium in differentiated but not undifferentiated PC12 cells.},
  author={Giulia Arslan and Catalin M. Filipeanu and Eva Irenius and Bj{\"o}rn Kull and Emilio Clementi and Clemens Allgaier and David Erlinge and Bertil B. Fredholm},
  journal={Neuropharmacology},
  year={2000},
  volume={39 3},
  pages={482-96}
}
ATP-induced Ca2+ transients were examined in individual PC12 cells of a well defined clone, before and after treatment with nerve growth factor (NGF) to induce a neurone-like phenotype. Using reverse transcriptase PCR these cells were found to express mRNA for several P2 receptors. In undifferentiated cells the ATP-induced Ca2+ response was entirely dependent on Ca2+ influx, could not be mimicked by UTP, alpha,beta-methylene ATP or dibenzoyl ATP or be blocked by pyridoxalphosphate-6-azophenyl-2… CONTINUE READING

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