P2Y receptors activate neuroprotective mechanisms in astrocytic cells.

  title={P2Y receptors activate neuroprotective mechanisms in astrocytic cells.},
  author={Nataliya E. Chorna and Laura I. Santiago-P{\'e}rez and Laurie Erb and Cheikh I. Seye and Joseph T. Neary and Grace Y Sun and G A Weisman and F. A. Castillo Gonz{\'a}lez},
  journal={Journal of neurochemistry},
  volume={91 1},
Mechanical or ischemic trauma to the CNS causes the release of nucleotides and other neurotransmitters into the extracellular space. Nucleotides can activate nucleotide receptors that modulate the expression of genes implicated in cellular adaptive responses. In this investigation, we used human 1321N1 astrocytoma cells expressing a recombinant P2Y2 receptor to assess the role of this receptor in the regulation of anti-apoptotic (bcl-2 and bcl-xl) and pro-apoptotic (bax) gene expression. Acute… CONTINUE READING


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