P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.

  title={P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.},
  author={Shengpeng Wang and Andr{\'a}s Iring and Boris Strili{\'c} and Juli{\'a}n Albarr{\'a}n Ju{\'a}rez and Harmandeep Kaur and Kerstin Troidl and Sarah Tonack and Joachim C. Burbiel and Christa E. M{\"u}ller and Ingrid Fleming and Jon O. Lundberg and Nina Wettschureck and Stefan Offermanns},
  journal={The Journal of clinical investigation},
  volume={125 8},
Elevated blood pressure is a key risk factor for developing cardiovascular diseases. Blood pressure is largely determined by vasodilatory mediators, such as nitric oxide (NO), that are released from the endothelium in response to fluid shear stress exerted by the flowing blood. Previous work has identified several mechanotransduction signaling processes that are involved in fluid shear stress-induced endothelial effects, but how fluid shear stress initiates the response is poorly understood… CONTINUE READING
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