P2Y(2) receptor-mediated proliferation of C(6) glioma cells via activation of Ras/Raf/MEK/MAPK pathway.

@article{Tu2000P2Y2RP,
  title={P2Y(2) receptor-mediated proliferation of C(6) glioma cells via activation of Ras/Raf/MEK/MAPK pathway.},
  author={M. Tuan Tu and Shanghua Luo and Chih Chien Wang and Chi Sheng Chien and Christopher T Chiu and Curtis Chun-Jen Lin and Chuen-Mao Yang},
  journal={British journal of pharmacology},
  year={2000},
  volume={129 7},
  pages={
          1481-9
        }
}
  • M. Tuan Tu, Shanghua Luo, +4 authors Chuen-Mao Yang
  • Published in
    British journal of…
    2000
  • Medicine, Chemistry
  • 1. Extracellular purine and pyrimidine nucleotides have been implicated in the regulation of several cellular functions including mitogenesis. In this study, experiments were conducted to characterize the P2Y receptor on C(6) glioma cells responsible for stimulating cell proliferation associated with mitogen-activated protein kinase (MAPK) activation. 2. UTP and ATP produced a similar effect on [(3)H]-thymidine incorporation in a time- and concentration-dependent manner, suggesting the… CONTINUE READING

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