P2Y(2) nucleotide receptor signaling in human monocytic cells: activation, desensitization and coupling to mitogen-activated protein kinases.

@article{SantiagoPrez2001P2Y2NR,
  title={P2Y(2) nucleotide receptor signaling in human monocytic cells: activation, desensitization and coupling to mitogen-activated protein kinases.},
  author={Laura I. Santiago-P{\'e}rez and Rosa V. Flores and Cynthia Santos-Berrios and Nataliya E. Chorna and Brent Krugh and Richard C. Garrad and Laurie Erb and G A Weisman and F. A. Castillo Gonz{\'a}lez},
  journal={Journal of cellular physiology},
  year={2001},
  volume={187 2},
  pages={196-208}
}
Activation of P2Y(2) receptors by extracellular nucleotides has been shown to induce phenotypic differentiation of human promonocytic U937 cells that is associated with the inflammatory response. The P2Y(2) receptor agonist, UTP, induced the phosphorylation of the MAP kinases MEK1/2 and ERK1/2 in a sequential manner, since ERK1/2 phosphorylation was abolished by the MEK1/2 inhibitor PD 098059. Other results indicated that P2Y(2) receptors can couple to MAP kinases via phosphatidylinositol 3… CONTINUE READING

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