P2Y(1) receptor mediated neuronal fibre outgrowth in organotypic brain slice co-cultures.

@article{Heine2015P2Y1RM,
  title={P2Y(1) receptor mediated neuronal fibre outgrowth in organotypic brain slice co-cultures.},
  author={Claudia Heine and Katja Sygnecka and Nico Scherf and Marcus Grohmann and Annett Braesigk and Heike Franke},
  journal={Neuropharmacology},
  year={2015},
  volume={93},
  pages={252-66}
}
Extracellular purines have multiple functional roles in development, plastic remodelling, and regeneration of the CNS by stimulating certain P2X/Y receptor (R) subtypes. In the present study we elucidated the involvement of P2YRs in neuronal fibre outgrowth in the developing nervous system. We particularly focused on the P2Y1R subtype and the dopaminergic system, respectively. For this purpose, we used organotypic slice co-cultures consisting of the ventral tegmental area/substantia nigra (VTA… CONTINUE READING