P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis

@article{Panupinthu2008P2X7RO,
  title={P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis},
  author={Nattapon Panupinthu and Joseph T. Rogers and Lin Zhao and Luis Pastor Solano-Flores and Fred Possmayer and Stephen Michael Sims and S. Jeffrey Dixon},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={181},
  pages={859 - 871}
}
Nucleotides are released from cells in response to mechanical stimuli and signal in an autocrine/paracrine manner through cell surface P2 receptors. P2rx7-/- mice exhibit diminished appositional growth of long bones and impaired responses to mechanical loading. We find that calvarial sutures are wider in P2rx7-/- mice. Functional P2X7 receptors are expressed on osteoblasts in situ and in vitro. Activation of P2X7 receptors by exogenous nucleotides stimulates expression of osteoblast markers and… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 75 extracted citations

P2X7 receptors: role in bone cell formation and function.

Journal of molecular endocrinology • 2015
View 6 Excerpts
Highly Influenced

P2X7 Receptor Function in Bone-Related Cancer

Journal of osteoporosis • 2012
View 9 Excerpts
Highly Influenced

Tension Force-Induced ATP Promotes Osteogenesis Through P2X7 Receptor in Osteoblasts

Journal of cellular biochemistry • 2015
View 3 Excerpts
Highly Influenced

Purinergic signalling in osteoblasts.

Frontiers in bioscience • 2012
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 35 references

ATP release mediates fluid flow-induced proliferation of human bone marrow stromal cells.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2007

Critical role of the extracellular signal – regulated kinase – MAPK pathway in osteoblast differentiation and skeletal development

D. J. Geist, D. Liu, H. J. Donahue, R. L. Duncan
J . Cell Biol . • 2007

Molecular physiology of P 2 X receptors

J. C. Utting, A. Brandao-Burch, +3 authors T. R. Arnett
Physiol . Rev . • 2007

Physiology and pathophysiology of purinergic neurotransmission

S. Neidhart, E. Kawashima, M. Kosco-Vilbois, R. A. North, G. Buell
Physiol . Rev . • 2007

Fluid shear - induced ATP secretion mediates prostaglandin release in MC 3 T 3E 1 osteoblasts

T. Banovic, D. Naot, +3 authors J. Cornish
J . Bone Miner . Res . • 2005

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors.

Proceedings of the National Academy of Sciences of the United States of America • 2005

Similar Papers

Loading similar papers…