P2X7 receptor positively regulates MyD88-dependent NF-κB activation.

  title={P2X7 receptor positively regulates MyD88-dependent NF-κB activation.},
  author={Yanhui Liu and Yajuan Xiao and Zhi-yuan Li},
  volume={55 2},
Recent studies have demonstrated that P2X7 plays a critical role in the immune system. Here, our results showed that P2X7 activated a NF-κB - but not an IFN-β-dependent luciferase reporter gene in HEK293T cells. P2X7 was involved in the LPS- and ATP-induced NF-κB activation but did not significantly impact the response to Zymosan in RAW264.7 cells. The activation of NF-κB and IFN-β induced by myeloid differentiation primary-response protein 88 (MyD88) was enhanced by P2X7 co-expression. The… CONTINUE READING


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