P2X7 receptor polymorphism impairs extracellular adenosine 5′-triphosphate-induced interleukin-18 release from human monocytes

@article{Sluyter2004P2X7RP,
  title={P2X7 receptor polymorphism impairs extracellular adenosine 5′-triphosphate-induced interleukin-18 release from human monocytes},
  author={Ronald Sluyter and JG Dalitz and JS Wiley},
  journal={Genes and Immunity},
  year={2004},
  volume={5},
  pages={588-591}
}
Interleukin (IL)-18 is an important proinflammatory cytokine processed and released from cells of the monocyte lineage by activation of the P2X7 receptor by extracellular adenosine 5′-triphosphate (ATP). We examined if a loss-of-function polymorphism of the human P2X7 receptor (glutamic acid-496 to alanine) impairs this process. Using a whole blood-based assay, ATP-induced release of IL-18 from homozygous subjects after 120 min incubation with ATP was 42% of that from wild-type subjects… CONTINUE READING

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