P2X7 receptor gene polymorphism analysis in rheumatoid arthritis.

  title={P2X7 receptor gene polymorphism analysis in rheumatoid arthritis.},
  author={Ahmed K Al-Shukaili and Juma M. Al-Kaabi and Batool Hassan and Tariq Al-Araimi and Mohammed Al-Tobi and Mohammed Nasser Al-Kindi and Abdullah Ali Nasser Al-Maniri and Ammar Al-gheilani and Alia Al-Ansari},
  journal={International journal of immunogenetics},
  volume={38 5},
The P2X7 receptor, a member of the P2X family of nucleotide-gated channels, is predominantly expressed by monocytic cells. The activation of this receptor has been associated with downstream-signalling cascades, resulting in the release of a number of inflammatory mediators. There are more than 815 single nucleotide polymorphisms (SNPs) that have been described in the human P2X7R gene, but only few have been functionally characterized. The main aim of this study is to determine whether P2X7R… CONTINUE READING