P2X7 receptor-dependent cell death is modulated during murine T cell maturation and mediated by dual signaling pathways.

@article{Tsukimoto2006P2X7RC,
  title={P2X7 receptor-dependent cell death is modulated during murine T cell maturation and mediated by dual signaling pathways.},
  author={Mitsutoshi Tsukimoto and Machiko Maehata and Hitoshi Harada and Akira Ikari and Kuniaki Takagi and Masakuni Degawa},
  journal={Journal of immunology},
  year={2006},
  volume={177 5},
  pages={2842-50}
}
Extracellular ATP causes apoptosis and/or necrosis of the hemopoietic lineage through the activation of P2X7 receptors. In this study, we investigated P2X7 receptor-mediated cell death during murine T cell maturation. The expression level and activity of P2X7 receptors, as measured by induction of cell death and pore formation, were higher in splenocytes… CONTINUE READING