P2X7 receptor cross-talk regulates ATP-induced pannexin 1 internalization.

Abstract

In the nervous system, extracellular ATP levels transiently increase in physiological and pathophysiological circumstances, effecting key signalling pathways in plasticity and inflammation through purinergic receptors. Pannexin 1 (Panx1) forms ion- and metabolite-permeable channels that mediate ATP release and are particularly enriched in the nervous system… (More)
DOI: 10.1042/BCJ20170257

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