P2X7 receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats

The P2X7 receptor is a ligand-gated ion channel activated by extracellular ATP, and a common genetic variation in the P2X7 gene significantly affects blood pressure. P2X7 receptor expression is associated with renal injury and some inflammatory diseases. Brilliant blue G (BBG) is a selective rat P2X7 receptor antagonist. In this study, to test whether BBG… CONTINUE READING