P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment

Abstract

Duchenne muscular dystrophy (DMD) is a lethal inherited muscle disorder. Pathological characteristics of DMD skeletal muscles include, among others, abnormal Ca(2+) homeostasis and cell signalling. Here, in the mdx mouse model of DMD, we demonstrate significant P2X7 receptor abnormalities in isolated primary muscle cells and cell lines and in dystrophic… (More)
DOI: 10.1111/j.1582-4934.2011.01397.x

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@inproceedings{Young2012P2X7PA, title={P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment}, author={Christopher J Young and Wojciech Brutkowski and C L Lien and Stephen Arkle and Hanns Lochm{\"u}ller and Krzysztof Zabłocki and Dariusz C. G{\'o}recki}, booktitle={Journal of cellular and molecular medicine}, year={2012} }